Arthritic diseases are a major cause of disability and morbidity, and cause an enormous burden for health and social care systems. Osteoarthritis is the most common form of arthritis and the focus of Professor Mobasheri’s research. His enlightening lecture today has helped us understand that while some important factors for the development of osteoarthritis are age, obesity and joint trauma, there is accumulating evidence suggesting that OA is a whole-organ disease that is influenced by systemic mediators. During his presentation, Profesor Mobasheri explored the immunometabolic alteration that occurs in cartilage and synovium during joint inflammation. Using a Seahorse analyzer to measure oxygen consumption rate and extracellular acidification rate of live cells, Profesor Mobasheri was able to analyze cellular functions such as mitochondrial respiration and glycolysis to outline such metabolic alterations at the cellular level, focusing especially on metabolic reprogramming in chondrocytes in response to pro-inflammatory cytokines.
Professor Mobasheri is the President of the Osteoarthritis Research Society International (OARSI), the leading medical society for advancing the understanding, early detection, treatment and prevention of osteoarthritis (OA) through its exclusive dedication to research. He is also Professor of Musculoskeletal Biology in the Research Unit of Medical Imaging, Physics and Technology within the Faculty of Medicine at the University of Oulu in Finland as well as Professor, Project Leader and Senior Research Scientist in the Department of Regenerative Medicine at the State Research Institute Centre for Innovative Medicine in Vilnius, Lithuania. We are very grateful for his time today as his current appointments keep him busy traveling between Finland, Lithuania, the UK and more.