Academic title(s): 

Professor (tenured), Department of Surgery, McGill University

Professor, Joint, Dept. of Human Genetics, McGill University

Professor, Joint, Dept. of Medicine, McGill University

Francis Glorieux Professor of Pediatric Musculoskeletal Research, McGill University

Position(s): 

Shriners Investigator, RI-MUHC

Research Interests: 

Dr St-Arnaud is interested in the control of gene expression in bone cells as well as in vitamin D metabolism. His laboratory uses state-of-the-art techniques in molecular biology and molecular genetics to identify and characterize regulators of gene expression in osteoblasts and to develop animal models of metabolic bone disease.

His group has made significant contributions to our understanding of bone cell differentiation and function: they have cloned the 25-hydroxyvitamin D-1-alpha-hydroxylase gene (Cyp27b1), characterized the role of the aNAC transcriptional coregulator molecule in bone, isolated and characterized the Factor Inhibiting ATF4-mediated Transcription, and cloned a novel membrane receptor for 24, 25-dihydroxyvitamin D. Dr. St-Arnaud’s long-term goals include the study of the molecular mechanisms and signal transduction cascades involving the genes that was cloned, in order to identify ‘druggable’ targets for the treatment of fractures and metabolic bone diseases.

Biography: 

Dr. René St-Arnaud, Ph.D., is the inaugural Francis Glorieux Professor in Pediatric Musculoskeletal Research. He is currently Director of Research at Shriners Hospital for Children – Canada in Montreal. He also holds cross-appointments as a tenured Full Professor of Medicine, Surgery, and Human Genetics at McGill University. He is an Associate Member of McGill’s Faculty of Dentistry. His research efforts are focused on vitamin D metabolism as well the control of gene expression in bone-forming cells. His contributions to the understanding of bone cell differentiation and function have been recognized through several distinctions, most recently the C.P. Leblond Career Award. Since the beginning of his career as an independent scientist, Dr. St-Arnaud has supervised over 45 graduate students and postdoctoral trainees. He has more than 140 peer-reviewed publications and 40 book chapters or conference proceedings. Dr. St-Arnaud was Director of the Network for Oral and Bone Health Research from 2008 to 2012 and President of Advances in Mineral Metabolism (2011-2013). In 2017, he completed a mandate as Chair of the Canadian Council on Animal Care, the national organization responsible for setting, maintaining, and overseeing the implementation of high standards for animal ethics and care in science throughout Canada.

Degree(s): 

B.Sc. Biochemistry, University of Montreal, Montreal.

Ph.D. in Physiology, Université Laval

Post-doctoral training, molecular biology, University of Ottawa and State University of New York at Stony Brook

Location: 

The Shriners Hospital for Children

1003 Decarie Blvd, Montreal, Quebec H4A 0A9